The Approval And Use Of Novel IBS Medications
Irritable bowel syndrome is a disorder characterized by abdominal pain, bloating, and discomfort. It is known as a functional disorder, meaning that it is entirely defined by the symptoms because the underlying causes are unknown. Similarly, for reasons unknown a bowel movement helps relieve these symptoms.
The NIH (National Institutes of Health) has issued a frightening report that some 60 million Americans exhibit one or more of the symptoms of IBS. However, they caution that because the symptoms are occasionally quite vague, the real number carries some uncertainty.
A subclass of IBS is additionally characterized by constipation making it difficult to carry out a bowel movement to relieve pain. At the moment, due to its cause being completely unknown, there is no treatment for this disorder.
Laxatives help reduce the effects of constipation, but they do not address the pain and may in fact make it worse. Pain killers that address the pain occasionally increase the severity of constipation. People with IBS C, as the condition is called, are stuck between a rock and the hard place.
An exciting new medication known by its scientific name as linaclotide has come to the foreground. It has passed several Phase 2 trials and surmounted hurdles for a defining Phase 3 trial. This drug is touted by many as a wonder drug for IBS C because it addresses both constipation and pain simultaneously.
In early September of 2010, linaclotide has yet to pass the final barrier to FDA approval. Positive results from a more preliminary trial has excited both patients and investors of Ironwood Pharmaceuticals, who holds the wrights to the drug. In the near time, many are waiting and watching for the results of the final Phase 3 results.
Numerous classes of laxatives are available to people with issues of constipation. Amongst the most popular are the well understood osmotic laxatives and the stimulant laxatives. The agents are named for what seems to be their mechanism of action. A well-known product marketed as Macrogol is a kind of osmotic agent, as well as magnesium-containing agents such as magnesium citrate or milk of magnesia.
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